I estimate that this medicine is of no effect.

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Iestimatethatthismedicineisofnoeffect.Iestimatethatthismedicineisofnoeffect.Iestimatethatthismedicin

I estimate that this medicine is of no effect.
I estimate that this medicine is of no effect.

I estimate that this medicine is of no effect.
我估计这种药没有效果.

我预计这药没用。