英语翻译Since the discovery of endogenous opiate receptors in the1970s [1-3],followed by the characterization of endogenousopioid peptides [4],the opioid system has been extensivelystudied.The endogenous opioid system is consists of four distinct

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英语翻译Sincethediscoveryofendogenousopiatereceptorsinthe1970s[1-3],followedbythecharacterizationofendog

英语翻译Since the discovery of endogenous opiate receptors in the1970s [1-3],followed by the characterization of endogenousopioid peptides [4],the opioid system has been extensivelystudied.The endogenous opioid system is consists of four distinct
英语翻译
Since the discovery of endogenous opiate receptors in the
1970s [1-3],followed by the characterization of endogenous
opioid peptides [4],the opioid system has been extensively
studied.The endogenous opioid system is consists of four distinct
neuronal systems that are widely distributed throughout
the CNS and peripheral organs.The four precursors are proopiomelanocortin,
proenkephalin,prodynorphin and pronociceptin/
orphanin FQ,each generating biologically active
peptides that are released at the synaptic terminals of opioidergic
neurons.These peptides exert their physiological
actions by interacting with the various classes of opioid
receptors present on both pre- and postsynaptic membranes
of opioid and opioid target neurons [5].
The most important opioid peptides seem to be the
pentapeptides enkephalins,which interact with both μ- and
δ-receptors,their affinity being significantly better for the
latter.This has triggered intensive studies to elucidate the role
of enkephalins in the brain,and to develop putative novel
effective treatments mainly in the field of analgesia and CNS
disorders,such as depression (review in [6,7]).

英语翻译Since the discovery of endogenous opiate receptors in the1970s [1-3],followed by the characterization of endogenousopioid peptides [4],the opioid system has been extensivelystudied.The endogenous opioid system is consists of four distinct
自从发现内源性阿片受体
70年代[1 - 3),其次是内生的表征
阿片肽[4],阿片系统已经广泛
研究.
的内源性阿片系统是由四个不同
神经系统,广泛地分布于整个
中枢神经和周边的器官.
proopiomelanocortin四个前兆,
proenkephalin,prodynorphin和pronociceptin /
匀浆中孤啡肽含量,每个产生生物活性
释放肽opioidergic在突触终端
神经元.
这些肽段发挥出自己的生理
行动,靠著与阿片各阶级
受体都出现在售前和突触后膜
阿片与阿片目标神经元[5].
最重要的阿片肽似乎
enkephalins胸腺五肽,相互影响、相互作用和μ-
δ-receptors,他们被较佳,并达显著程度的亲和力
后者.
这所引发的密集的研究,阐明这个角色
enkephalins的大脑发展潜在的小说
有效的治疗方法主要有,在这一领域的镇痛和中枢神经系统
疾病,如抑郁症(评在文献[6、7]).

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