求1篇文章的SCI收录号【作者(必填)】FEI Yan,LU Guo-cai,FAN Guo-rong,QI Yun-peng,WU Hui-ling,WU Yu-tian【文题(必填)】Studies on interaction of sinafloxacin with bovine serum albumin and effect of the coexistent metal ions on the reac
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求1篇文章的SCI收录号【作者(必填)】FEI Yan,LU Guo-cai,FAN Guo-rong,QI Yun-peng,WU Hui-ling,WU Yu-tian【文题(必填)】Studies on interaction of sinafloxacin with bovine serum albumin and effect of the coexistent metal ions on the reac
求1篇文章的SCI收录号
【作者(必填)】FEI Yan,LU Guo-cai,FAN Guo-rong,QI Yun-peng,WU Hui-ling,WU Yu-tian
【文题(必填)】Studies on interaction of sinafloxacin with bovine serum albumin and effect of the coexistent metal ions on the reaction
【期刊名,年份,卷(期),起止页码(必填)】spectroscopy and spectral analysis,2008,28(11)2609-2614
别搞错了啊,是SCI收录号,即 UT ISI:是十几位的数字
求1篇文章的SCI收录号【作者(必填)】FEI Yan,LU Guo-cai,FAN Guo-rong,QI Yun-peng,WU Hui-ling,WU Yu-tian【文题(必填)】Studies on interaction of sinafloxacin with bovine serum albumin and effect of the coexistent metal ions on the reac
UT ISI:000261459900035
在SCI搜索到你的文章后,点击 保存,如下图:
选择任何一种文献引用的保存格式保存,用记事本打开,就可以看见了!
下面是我打开的HTML文件的全文,UT ISI在导数第三行
FN ISI Export Format
VR 1.0
PT J
AU Fei, Y
Lu, GC
Fan, GR
Qi, YP
Wu, HL
Wu, YT
AF Fei Yan
Lu Guo-cai
Fan Guo-rong
Qi Yun-peng
Wu Hui-ling
Wu Yu-tian
TI Studies on Interaction of Sinafloxacin with Bovine Serum Albumin and Effect of the Coexistent Metal Ions on the Reaction
SO SPECTROSCOPY AND SPECTRAL ANALYSIS
LA Chinese
DT Article
DE Sinafloxacin; Bovine serum albumin; Fluorescence; Energy transition
ID FLUORESCENCE-SPECTRA
AB Serum albumin is the most abundant protein in plasma. It can bind with many intrinsic and extrinsic materials. The study of the interaction between serum albumin and drugs is a very important task in life science and chemistry. Quinolone drug is a kind of antibacterial drugs which have been used widely in clinical medicine, but its pharmacology and toxicology still have to be studied further. Sinafloxacin is a new quinolone antibiotics. The interaction between sinafloxacin and bovine serum albumin (BSA) at different temperatures and pH was investigated by fluorescence and UV absorption spectroscopy. The experimental results demonstrate that the fluorescence quenching of BSA by sinafloxacin is a result of the formation of sinafloxacin-BSA complex and the quenching mechanism is mainly static quenching. The interaction association constants of BSA and sinafloxacin were determined from the double reciprocal Lineweaver-Burk plot. The binding distance (r=3.64 nm)and energy transfer efficiency (E = 0.163) between donor(BSA)and acceptor (sinafloxacin) were obtained based on Forster's non-radiative energy transfer theory. There is a strong interaction between sinafloxacin and BSA. From thermodynamic coordination it can be judged that the binding force between sinafloxacin and BSA is mainly electrostatic force. The effect of sinafloxacin on the conformation of BSA was analyzed by synchronous fluorescence spectrometry and three-dimensional fluorescence spectrometry. The emission maximum of tyrosine residues does not show a significant shift, while the small blue shift of tryptophan residues indicates that the hydrophobicity of microenvironment was increased. In addition, in the plasma, there are some metal ions, which can participate in many important vital actions and affect the reactions of the drugs with the serum albumins. So the effect of Cu(II), Fe(III), Zn(II) and Mg(II) on the binding constant of sinafloxacin to BSA was also discussed and it was shown that the interaction between BSA and sinafloxacin was decreased. In short, the results offer a reference for the studies on the biological effects and action mechanism of sinafloxacin with albumins in vivo.
C1 [Fei Yan; Fan Guo-rong; Qi Yun-peng; Wu Hui-ling; Wu Yu-tian] Mil Med Coll 2, Sch Pharm, Shanghai Key Lab Pharmaceut Metabolites Res, Shanghai 200433, Peoples R China.
[Lu Guo-cai] Mil Med Coll 2, Ctr New Drug Evaluat, Inst Basic Med Sci, Shanghai 200433, Peoples R China.
RP Fan, GR, Mil Med Coll 2, Sch Pharm, Shanghai Key Lab Pharmaceut Metabolites Res, Shanghai 200433, Peoples R China.
NR 17
TC 1
PU BEIJING UNIV PRESS
PI BEIJING
PA HAIDIAN-QU, BEIJING 100871, PEOPLES R CHINA
SN 1000-0593
J9 SPECTROSC SPECTR ANAL
JI Spectrosc. Spectr. Anal.
PD NOV
PY 2008
VL 28
IS 11
BP 2609
EP 2614
DI 10.3964/j.issn.1000-0593(2008)11-2609-06
PG 6
SC Spectroscopy
GA 380IR
UT ISI:000261459900035
ER
EF