英语翻译Hollow polymeric spheres have been attracting increasinginterest because of their potential applications,which rangefrom targeted drug delivery to advanced functional materi-als.[1,2] Because of their hollow core structure,such polymerics

英语翻译Hollow polymeric spheres have been attracting increasinginterest because of their potential applications,which rangefrom targeted drug delivery to advanced functional materi-als.[1,2] Because of their hollow core structure,such polymerics
英语翻译
Hollow polymeric spheres have been attracting increasing
interest because of their potential applications,which range
from targeted drug delivery to advanced functional materi-
als.[1,2] Because of their hollow core structure,such polymeric
spheres can encapsulate large quantities of guest moleculesÐ
especially those spheres with functionalities within the empty
coreÐand release them at a later stage in a controlled man-
ner.Although hollow polymeric spheres with dimensions in
the micrometer and submicrometer regions are readily con-
structedÐby layer-by-layer deposition of polyelectrolytes
onto a template core,[3±6] polymerizing monomers in lipid vesi-
cles,[7,8] emulsion polymerization,[9,10] pH-induced micelliza-
tion of a grafted copolymer,[11] and by the assembly of posi-
tively charged polyelectrolytes and negatively charged
nanoparticles[12]Ðthe synthesis of hollow spheres 100 nm or
less in size has only recently become the subject of research
activity.Several different routes,such as the self-assembly of
block copolymers in a selective solvent,[13,14] the deposition of
polyelectrolytes on a decomplexable or soluble core,[15,16] and
microemulsion (as well as miniemulsion) polymerization,[17,18]
have been developed to form hollow polymeric nanospheres.
Although some of these methods have been quite successful,
these strategies require the core templates to be removed in
order to create a hollow interior,or need large quantities of
surfactants to form nanosized micelles.Furthermore,although
the majority of the proposed applications of hollow nano-
spheres or nanocapsules are concentrated in the biomedical
field,most of the hollow polymeric spheres described to date
are ill-suited for such purposes.Therefore,materials (in par-
ticular for the surfaces of the hollow nanospheres) that are
biocompatible,non-toxic,and sometimes also biodegradable,
are highly desirable.Herein,we demonstrate a simple and di-
rect method for fabricating hollow polymeric nanospheres
with biocompatible and biodegradable macromolecules.In
this approach,hollow polymeric nanospheres were formed in
a completely aqueous system without the aid of surfactants,

英语翻译Hollow polymeric spheres have been attracting increasinginterest because of their potential applications,which rangefrom targeted drug delivery to advanced functional materi-als.[1,2] Because of their hollow core structure,such polymerics
空心聚合物领域一直吸引着越来越多
兴趣,因为他们的潜在应用,范围
从有针对性的药物输送到高级功能马特里-
als.[1,2]因为他们的空心结构,这种聚合物
球体可以封装moleculesÐ大量的客人
尤其是球体与功能在空
coreÐand释放他们后来在一个受控的人-
押尼珥.虽然空心聚合物在球体的尺寸
千分尺及亚微米的区域很容易完全
structedÐby层沉积的聚合电解质
到一个模板的核心,[3±6]聚合单体在脂质vesi -
cles,[7,8]乳液聚合,(9、10)ph诱导micelliza -
接枝共聚物的名诗,[11]和组装及-
tively带电聚合电解质和带负电
[12]Ðthe合成纳米颗粒的空心球体100海里或
更少的大小只有最近成为研究的主题
活动.几个不同的路线,比如自组装的
嵌段共聚物在选择性溶剂,(13、14)的沉积
聚合电解质在decomplexable或可溶性核心,(15、16)和
微乳液(以及实验)聚合,(17、18)
已经开发形成空心聚合物纳米团簇.
尽管其中的一些方法已经相当成功,
这些策略需要核心模板被删除的
为了创建一个中空的内部,或者需要大量的
表面活性剂形成纳米胶束.此外,虽然
提出了应用程序的大多数的空心纳米-
球体或所研发的纳米囊是集中在生物医学
场,大部分的空心聚合物领域描述到目前为止
不适合这种用途.因此,材料(par -
单独的表面的空心纳米团簇)
生物相容性、无毒、可生物降解,有时也
是非常可取的.在此,我们演示一个简单的和di -
矩形法制造空心聚合物纳米团簇
同的生物相容性和可降解性高分子.在
这种方法,空心聚合物纳米团簇的形成
一个完全水系统的帮助下表面活性剂,