为什么内质网可以起到质量监控作用?
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为什么内质网可以起到质量监控作用?
为什么内质网可以起到质量监控作用?
为什么内质网可以起到质量监控作用?
质量监控作用包括：（1）未折叠蛋白质应答反应,及错误折叠与未折叠蛋白质不能按正常途径从内质网中释放,从而在内质网腔内聚集,一起一系列分子伴侣和折叠没表达上调,促进蛋白质正确折叠,防止其聚集,从而提高细胞在有害因素下生存能力.（2)内质网超负荷反应,正确折叠的蛋白质在内质网过度储积,特别是因膜蛋白在内质网异常堆积也会启动其他促生存的机制来反制内质网压力.（3）固醇调节级联反应,内固醇表面合成的胆固醇损耗所致,通过固醇调节元件结合蛋白质介导的信号途径,影响特定基因表达.（4）如果内质网功能紊乱,细胞将最终启动凋亡程序.
The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum.
The UPR is activated in response to an accumulation of unfolded or misfolded proteins in th...
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The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum.
The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum. In this scenario, the UPR has two primary aims: initially to restore normal function of the cell by halting protein translation and activate the signaling pathways that lead to increasing the production of molecular chaperones involved in protein folding. If these objectives are not achieved within a certain time lapse or the disruption is prolonged, the UPR aims towards apoptosis.
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