英语翻译Our study also addressed the role of extrinsic in-nervation in postprandial absorption.The study wasdesigned to determine whether extrinsic innervationplays a role in mediating postprandial augmenta-tion in net absorptions.Net ileal absor
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英语翻译Our study also addressed the role of extrinsic in-nervation in postprandial absorption.The study wasdesigned to determine whether extrinsic innervationplays a role in mediating postprandial augmenta-tion in net absorptions.Net ileal absor
英语翻译
Our study also addressed the role of extrinsic in-
nervation in postprandial absorption.The study was
designed to determine whether extrinsic innervation
plays a role in mediating postprandial augmenta-
tion in net absorptions.Net ileal absorption of glu-
cose and glutamine in the early postprandial period
was decreased.These decreases in absorption were
not a nonspecific global event,because there was no
postprandial effect on absorption of oleic acid or taur-
ocholate at any time point.Also,there were no gross
changes in transit after feeding that might explain a
decrease in absorption.In addition,although we did
not evaluate intestinal morphology in this experi-
ment,we have shown previously that gross mucosal
morphology does not change with this preparation.
Our previous work and that of others have re-
peatedly shown a marked weight loss after in situ
neural isolation(extrinsic denervation)of the jeju-
noileum
and after jejunoileal autotransplanta-
tion.23,24 The primary cause or causes of this weight
loss have remained elusive.Multiple studies of net
absorptive function in the whole dog and specifically
in jejunum17,25 and ileum18,26 have shown statisti-
cally significant although relatively minor decreases
on baseline absorption during fasting that do not
appear great enough alone to explain either the pro-
fuse watery diarrhea or the weight loss that are
soprominent in the first 2 to 3 weeks after these models
of small bowel autotransplantation.The decrease in
net absorption of the simple solutes(glucose,gluta-
mine)in the early postprandial period may help to
explain these previous observations.Also of interest is
the finding that this postprandial decrease is transient.
Early postprandial net absorption had returned to
normal when measured at 12 weeks after extrinsic
denervation,a time when the watery diarrhea had
also resolved and the dogs had regained the weight
they lost in the early postoperative period.This
postprandial decrease in net absorption may have
translational importance in the field of clinical SBT.
Weight loss and diarrhea occur after SBT in humans,
and the mechanism(s)remains largely unknown
英语翻译Our study also addressed the role of extrinsic in-nervation in postprandial absorption.The study wasdesigned to determine whether extrinsic innervationplays a role in mediating postprandial augmenta-tion in net absorptions.Net ileal absor
我们的研究也同时提出了外部神经调节在餐后吸收中的作用.这个研究是为了调查外部神经系统是否会调节餐后敬吸收的增加而设计的.
在餐后的早期时间里,大肠对葡萄糖和谷氨酸盐的吸收是下降的.
这些吸收的下降并是一个特殊的全球化事件,因为在餐后任何时间都不会影响对油酸或者牛黄胆酸的吸收.同样,在吃完饭后也没有运送的总变动值,这或许可以解释吸收下降这一现象.
另外,虽然在实验中我们没有重新估算肠粘膜的形态,但是先前我们证明了在准备过程中肠粘膜的形态不会改变.
我们之前的工作还有别人的工作都反复证明了空回肠的原位神经分(外在神经)或者空回肠自体移植后都有一个显著的体重下降.
最本质的引起体重下降的原因,或者说原因们仍然扑朔迷离.
关于净吸收的多样研究在整狗试验尤其是空肠和回肠都显出了很大的影响,虽然说与节食相伴的吸收基线微弱下降不足以解释在小肠自体移植后的第一个2到3周内出现的极为明显的富含水的腹泻或者体重下降.
在餐后早些时候对简单溶解物(例如葡萄糖和谷氨盐酸)吸收的下降可以解释先前的观察.
还很有趣的就是发现这个吸收下降只是暂时性的.
当在12周外在神经调节后(并且在那时水性的腹泻停止而且狗也重新收复了在早期吸收时期丢失了的体重)测量时,早些时候的净吸收回归到原值.
这个餐后净吸收的下降将对临床SBT领域有重要作用.人体在SBT后体重
下降、腹泻,而那些机制仍然远远的不为人知.
我们的研究也演讲了角色的外在内部 在正餐后吸收的nervation。研究是确定是否的designed外在激动
plays在斡旋正餐后augmenta- 的一个角色在净吸收的tion。glu- 的净回肠的吸收在早期的正餐后期间的cose和谷氨酰胺减少的was。在吸收的这些减退是
not一个未指明的全球性事件,因为没有对十八烯酸或taur- 的吸收的postprandial作用在任何时...
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我们的研究也演讲了角色的外在内部 在正餐后吸收的nervation。研究是确定是否的designed外在激动
plays在斡旋正餐后augmenta- 的一个角色在净吸收的tion。glu- 的净回肠的吸收在早期的正餐后期间的cose和谷氨酰胺减少的was。在吸收的这些减退是
not一个未指明的全球性事件,因为没有对十八烯酸或taur- 的吸收的postprandial作用在任何时候ocholate点。并且,没有总
changes在运送中在也许解释的哺养以后在吸收的decrease。另外,虽然我们做了
not评估在这experi- 的小肠形态学ment,我们以前显示了那总黏膜
morphology不改变与这种准备。
Our以前的工作和那其他有再在原处以后显示的明显减重peatedlyneural隔离(外在去除神经支配)济州
noileum 在jejunoileal autotransplanta-以后的and
tion.23,这重量的24主要起因或起因loss保持逃避。净的多项研究在整体狗和明确地的absorptive作用in jejunum17,25和ileum18,26显示了statisti- 重大的cally,虽然较小的减退
on在斋戒期间的基础线吸收那不足够伟大的appear单独解释二者之一前的是的fuse水性腹泻或减重soprominent在这些模型以后的前2个到3个星期of小肠autotransplantation。在的减退简单的溶质(葡萄糖, gluta- 的net吸收mine)在早期的正餐后期间也许帮助到
explain这些早先观察。并且利益是发现的the这正餐后减退是瞬变的。
Early正餐后净吸收回到了
normal,当测量在外在以后的12个星期denervation,时候,当水性腹泻有
also被解决的和狗收复了重量在早期的手术后期间丢失的they。这在净吸收的postprandial减退也许有在临床SBT的领域的translational重要性。
Weight损失和腹泻在人的SBT, 以后发生and机制保持主要未知
收起
Our study also addressed the role of extrinsic in-
nervation in postprandial absorption.The study was
designed to determine whether extrinsic innervation
plays a role in mediating postp...
全部展开
Our study also addressed the role of extrinsic in-
nervation in postprandial absorption.The study was
designed to determine whether extrinsic innervation
plays a role in mediating postprandial augmenta-
tion in net absorptions.Net ileal absorption of glu-
cose and glutamine in the early postprandial period
was decreased.These decreases in absorption were
not a nonspecific global event,because there was no
postprandial effect on absorption of oleic acid or taur-
ocholate at any time point.Also,there were no gross
changes in transit after feeding that might explain a
decrease in absorption.In addition,although we did
not evaluate intestinal morphology in this experi-
ment,we have shown previously that gross mucosal
morphology does not change with this preparation.
Our previous work and that of others have re-
peatedly shown a marked weight loss after in situ
neural isolation(extrinsic denervation)of the jeju-
noileum
and after jejunoileal autotransplanta-
tion.23,24 The primary cause or causes of this weight
loss have remained elusive.Multiple studies of net
absorptive function in the whole dog and specifically
in jejunum17,25 and ileum18,26 have shown statisti-
cally significant although relatively minor decreases
on baseline absorption during fasting that do not
appear great enough alone to explain either the pro-
fuse watery diarrhea or the weight loss that are
soprominent in the first 2 to 3 weeks after these models
of small bowel autotransplantation.The decrease in
net absorption of the simple solutes(glucose,gluta-
mine)in the early postprandial period may help to
explain these previous observations.Also of interest is
the finding that this postprandial decrease is transient.
Early postprandial net absorption had returned to
normal when measured at 12 weeks after extrinsic
denervation,a time when the watery diarrhea had
also resolved and the dogs had regained the weight
they lost in the early postoperative period.This
postprandial decrease in net absorption may have
translational importance in the field of clinical SBT.
Weight loss and diarrhea occur after SBT in humans,
and the mechanism(s)remains largely unknown
我们的研究还讨论了角色的外在-
nervation在餐后吸收研究
设计,以确定是否外在支配
中的作用,在调解餐后增大-
审议净absorptions.net回肠吸收的谷氨酸
cose和谷氨酰胺在早期餐后期
被decreased.these跌幅吸收
不是一个非特异性的全球性活动,因为没有任何
餐后影响吸收的油酸或涛-
ocholate在任何时候point.also ,没有毛
变化过境喂养后可能解释
跌幅absorption.in此外,虽然我们并
没有评估肠道形态学在这个实验
ment ,我们已表现出以前认为毛粘膜
形态,并不能改变这个准备。
我们过去的工作和别人有重
peatedly表现出明显的体重减轻后,在原地
神经分离(外在神经)的济州-
noileum
之后,空回肠autotransplanta -
tion.23 , 24个主要的原因在这个重量
亏损依然elusive.multiple研究网
吸收功能,在整个狗和专门
在jejunum17日, 25日和ileum18 , 26显示statisti -
cally显着虽然较为轻微下跌
基线吸收禁食期间不
看来力度不够大,仅解释要么亲
保险丝水泻或体重减轻是
soprominent在第一批2到3个星期后,这些模式
小肠autotransplantation.the下降
净吸收的简单溶质(葡萄糖, gluta -
雷) ,在早期餐后期间可能会有帮助
解释这些以往observations.also感兴趣的是
这次调查发现,这餐后减少是短暂的。
早餐后净吸收已返回
正常时,测得12个星期后,外在
神经损伤,而当时水泻了
还解决和狗重获重量
他们迷失在术后早期period.this
餐后减少净吸收可能有
平移的重要性,在这一领域的临床小肠移植。
体重减轻,腹泻发生后,小肠移植在人类中,
及(或多个)机制在很大程度上仍未知
收起
我们的研究还讨论了角色的外在-
nervation在餐后吸收研究
设计,以确定是否外在支配
中的作用,在调解餐后增大-
审议净absorptions.net回肠吸收的谷氨酸
cose和谷氨酰胺在早期餐后期
被decreased.these跌幅吸收
不是一个非特异性的全球性活动,因为没有任何
餐后影响吸收的油酸或涛-
oc...
全部展开
我们的研究还讨论了角色的外在-
nervation在餐后吸收研究
设计,以确定是否外在支配
中的作用,在调解餐后增大-
审议净absorptions.net回肠吸收的谷氨酸
cose和谷氨酰胺在早期餐后期
被decreased.these跌幅吸收
不是一个非特异性的全球性活动,因为没有任何
餐后影响吸收的油酸或涛-
ocholate在任何时候point.also ,没有毛
变化过境喂养后可能解释
跌幅absorption.in此外,虽然我们并
没有评估肠道形态学在这个实验
ment ,我们已表现出以前认为毛粘膜
形态,并不能改变这个准备。
我们过去的工作和别人有重
peatedly表现出明显的体重减轻后,在原地
神经分离(外在神经)的济州-
noileum
之后,空回肠autotransplanta -
tion.23 , 24个主要的原因在这个重量
亏损依然elusive.multiple研究网
吸收功能,在整个狗和专门
在jejunum17日, 25日和ileum18 , 26显示statisti -
cally显着虽然较为轻微下跌
基线吸收禁食期间不
看来力度不够大,仅解释要么亲
保险丝水泻或体重减轻是
soprominent在第一批2到3个星期后,这些模式
小肠autotransplantation.the下降
净吸收的简单溶质(葡萄糖, gluta -
雷) ,在早期餐后期间可能会有帮助
解释这些以往observations.also感兴趣的是
这次调查发现,这餐后减少是短暂的。
早餐后净吸收已返回
正常时,测得12个星期后,外在
神经损伤,而当时水泻了
还解决和狗重获重量
他们迷失在术后早期period.this
餐后减少净吸收可能有
平移的重要性,在这一领域的临床小肠移植。
体重减轻,腹泻发生后,小肠移植在人类中,
及(或多个)机制在很大程度上仍未知
收起