外文翻译,求高人帮忙翻译下...谢谢!Microphthalmia-associated transcription factor (MITF)acts as a master regulator of melanocyte development,function and survival by modulating various differentiation and cell-cycle progression genes. It

外文翻译,求高人帮忙翻译下...谢谢!Microphthalmia-associated transcription factor (MITF)acts as a master regulator of melanocyte development,function and survival by modulating various differentiation and cell-cycle progression genes. It
外文翻译,求高人帮忙翻译下...谢谢!
Microphthalmia-associated transcription factor (MITF)
acts as a master regulator of melanocyte development,function and survival by modulating various differentiation and cell-cycle progression genes. It has been demonstrated that MITF is an amplified oncogene in a fraction of human melanomas and that it also has an oncogenic role in human clear cell sarcoma. However,
MITF also modulates the state of melanocyte differentiation.
Several closely related transcription factors also function as translocated oncogenes in various human malignancies. These data place MITF between instructing melanocytes towards terminal differentiation and/or pigmentation and, alternatively, promoting malignant behavior. In this review, we survey the roles of MITF as a
master lineage regulator in melanocyte development and its emerging activities in malignancy. Understanding the molecular function of MITF and its associated pathways will hopefully shed light on strategies for improving therapeutic approaches for these diseases.

外文翻译,求高人帮忙翻译下...谢谢!Microphthalmia-associated transcription factor (MITF)acts as a master regulator of melanocyte development,function and survival by modulating various differentiation and cell-cycle progression genes. It
Microphthalmia相关转录因子（ MITF ）
作为一个主控调节的黑素细胞的发展,功能和生存的各种调节分化和细胞周期的基因.已经证明,MITF是一种原癌基因扩增的一小部分人的黑色素瘤,它也有致癌作用,人类透明细胞肉瘤.但是,
MITF也调节状态的黑素细胞的分化.
一些密切相关的转录因子也可作为转基因在不同人的恶性肿瘤.这些数据的地方MITF黑色素细胞之间的指示走向终末分化和/或色素沉着,并交替,促进恶性行为.在这次审查中,我们调查的作用,作为一个MITF
主系调节黑色素细胞的发展和新兴活动的恶性肿瘤.了解分子功能的MITF及其相关途径有望揭示战略,以改善治疗方法对这些疾病.