英语翻译Whether melanogenesis occurs in adult eyes is still a matter of controversy.It has been widely held that the pigment epithelial cells are fully melanized at birth,and that the uveal melanocytes cease their melanin production in the very y

英语翻译Whether melanogenesis occurs in adult eyes is still a matter of controversy.It has been widely held that the pigment epithelial cells are fully melanized at birth,and that the uveal melanocytes cease their melanin production in the very y
英语翻译
Whether melanogenesis occurs in adult eyes is still a matter of controversy.It has been widely held that the pigment epithelial cells are fully melanized at birth,and that the uveal melanocytes cease their melanin production in the very young individual.Therefore there should be no turnover of melanin in the adult eye.
A number of studies have,however,demonstrated that the enzyme involved in melanin synthesis,tyrosinase,seems to be active also in the adult eye.The recent observation that a prostaglandin analogue,used in glaucoma therapy,caused increased iridal pigmentation in the treated eye,but not in the untreated eye,of adult monkeys and in humans,indicate that the adult eye at least has the capacity to produce melanin.In the present study 3H-methimazole,a false melanin precursor,was administered to a series of DBA-mice,3 weeks to one year of age.The eyes were removed 24 hr after a single i.p.injection of 3H-methimazole.Using microautoradiography the incorporation of radioactivity was studied in X-ray film covered sections comprising the entire eye.
A very selective accumulation of radioactivity was seen in uveal melanocytes and in the pigment epithelial cells in the iris and the ciliary body.The level in the retinal pigment epithelium was low in the eyes of all ages.No uptake was seen in any non-pigmented ocular tissue.The most pronounced accumulation was seen in the pigment epithelium and melanocytes in the iris of the young mice,but some activity was seen in these cells also in the older mice.The presence of immature melanosomes seen in electron micrographs from iridal pigment cells and melanocytes of one year old mice indicate that new melanosomes are formed in these cells also in adult animals.
The results of this study thus strongly indicate that there seems to be an active melanin synthesis in the adult eye of the mouse,most pronounced in iridal melanocytes and in the iridal pigment epithelium.

英语翻译Whether melanogenesis occurs in adult eyes is still a matter of controversy.It has been widely held that the pigment epithelial cells are fully melanized at birth,and that the uveal melanocytes cease their melanin production in the very y
无论是黑素瘤发生在成人眼中仍然是一个有争议的问题.人们普遍认为,色素上皮细胞得到充分melanized出生时,该葡萄膜黑素细胞停止生产黑色素在非常年轻的人.因此,不应该有营业黑色素在成人眼睛.
一些研究,但表明,这种酶参与黑色素合成,酪氨酸酶,似乎也活跃在成人眼睛.最近的观察,一个前列腺素类似物,用于治疗青光眼,造成色素沉着增加iridal在治疗眼睛,而不是在未经处理的眼睛,成年猴和人类表明,眼睛的成人至少有能力产生黑色素.在本研究中的3H -唑,虚假的黑色素前体,是管理的一系列管理员小鼠, 3周为一年以下.眼睛被拆除24小时后,一个单一的腹腔注射的3H -唑.使用microautoradiography把放射性研究了X光片组成部分涵盖了整个眼睛.
一个非常有选择性积累的放射性被视为在葡萄膜黑素细胞和色素上皮细胞和虹膜睫状体.该级别的视网膜色素上皮细胞是低的眼神,不分年龄人人共享的.没有摄取被视为在任何非色素眼组织.最明显的积累被视为在色素上皮细胞和黑素细胞中的虹膜的年轻老鼠,但有些活动是从这些细胞中老年人的作用.在场的不成熟黑素看到透射电镜从iridal色素细胞和黑色素细胞的1岁老鼠表明,新的黑素形成于这些细胞在成年动物.
这项研究的结果因此强烈表明,似乎是一种积极的黑色素合成成人眼睛的鼠标,最明显iridal黑色素细胞和色素上皮细胞iridal .

亲爱的，你不给分谁有那么多时间啊？？