英语翻译When PTEN is mutated,Akt signals via the NF-kappaB/I-kappaB pathway to induce COX-2 expression in endometrial cancer cells.COX-2 can inhibit apoptosis,increase angiogenesis,and promote invasiveness.COX-2 also promotes inflammation/immunos
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英语翻译When PTEN is mutated,Akt signals via the NF-kappaB/I-kappaB pathway to induce COX-2 expression in endometrial cancer cells.COX-2 can inhibit apoptosis,increase angiogenesis,and promote invasiveness.COX-2 also promotes inflammation/immunos
英语翻译
When PTEN is mutated,Akt signals via the NF-
kappaB/I-kappaB pathway to induce COX-2 expression
in endometrial cancer cells.COX-2 can inhibit apoptosis,
increase angiogenesis,and promote invasiveness.COX-
2 also promotes inflammation/immunosuppression and
conversion of procarcinogens into carcinogens that
contribute to tumorigenesis and a malignant phenotype.
This study demonstrated that Akt signals via the NF-
kappaB/I-kappaB pathway to induce COX2 gene and
protein expression in endometrial cancer .
英语翻译When PTEN is mutated,Akt signals via the NF-kappaB/I-kappaB pathway to induce COX-2 expression in endometrial cancer cells.COX-2 can inhibit apoptosis,increase angiogenesis,and promote invasiveness.COX-2 also promotes inflammation/immunos
当PTEN被诱导突变,AKt信号通过NF-KappaB/I-KappaB通道在子宫内膜的癌细胞中来诱导COX-2的表达.COX-2能够抑制癌细胞凋亡,增加血管的生成,提高了癌细胞的侵润能力.COX-2也能够加重炎症和免疫反应,同时使得原癌基因转变成为诱发肿瘤和恶性表型的癌基因.这项研究证明了
AKt的信号确实是通过NF-KappaB/I-KappaB通道在子宫内膜的癌细胞中来诱导COX-2基因和相关蛋白的表达来实现的.
当PTEN基因发生突变时, Akt信号通过NF-kappaB/I-kappaB增强COX -2的在子宫内膜癌细胞中的活性。 COX -2能抑制细胞死亡,增加血管新生,增强抵抗力。 COX -2也能促进细胞的炎症/免疫抑制和致癌物间的相互转变,这种转变会导致肿瘤发生和恶性表型。这项研究表明, Akt信号能通过NF -κB/ I - κB诱导COX-2基因生成,同时促进及子宫内膜癌的蛋白活性。...
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当PTEN基因发生突变时, Akt信号通过NF-kappaB/I-kappaB增强COX -2的在子宫内膜癌细胞中的活性。 COX -2能抑制细胞死亡,增加血管新生,增强抵抗力。 COX -2也能促进细胞的炎症/免疫抑制和致癌物间的相互转变,这种转变会导致肿瘤发生和恶性表型。这项研究表明, Akt信号能通过NF -κB/ I - κB诱导COX-2基因生成,同时促进及子宫内膜癌的蛋白活性。
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