英语翻译Chitosan-based scaffolds possess some specialproperties for use in tissue engineering.First,Chitosancan be formed as interconnected-porous structures byfreezing and lyophilizing of chitosan solution or byprocesses such as an “internal b

英语翻译Chitosan-based scaffolds possess some specialproperties for use in tissue engineering.First,Chitosancan be formed as interconnected-porous structures byfreezing and lyophilizing of chitosan solution or byprocesses such as an “internal b
英语翻译
Chitosan-based scaffolds possess some special
properties for use in tissue engineering.First,Chitosan
can be formed as interconnected-porous structures by
freezing and lyophilizing of chitosan solution or by
processes such as an “internal bubbling process (IBP)”
where CaCO3 is added to chitosan solutions to generate
chitosan–CaCO3 gels in specific shapes by using suitable
molds (Chow and Khor,2000).The interconnectedporous
structure is very important,so that numerous cells
can be seeded,migrate into the inside,increase the cell
number and should be supplied by sufficient amounts of
nutrient.The porous structure of chitosan is a promising
characteristic for the development and optimization of a
variety of tissue scaffolds and regeneration aids.Regulation
of porosity and pore morphology of chitosan-based
scaffolds is critical for controlling cellular colonization
rates and organization within an engineered tissue.In
addition,angiogenesis required for some scaffold application
scenarios can be affected by scaffold porosity and
pore morphology (Madihally and Matthew,1999).
Second,the cationic nature of chitosan also allows for
pH-dependent electrostatic interactions with anionic
glycosaminoglycans (GAG) and proteoglycans distributed
widely throughout the body and other negatively
charged species.This property is one of the important
elements for tissue engineering applications because
numbers of cytokines/growth factors are known to be
bound and modulated by GAG including heparin and
heparan sulfate.A scaffold incorporating a chitosan–
GAG complex may serve means of retaining and concentrating
desirable factors secreted by colonizing cells.
Moreover,Nishikawa et al.(2000) reported that chitosan,
structurally resembling with GAG consisting of longchain,
unbranched,repeating disaccharide units,regarded
to play a key role in modulating cell morphology,differentiation,
and function.

英语翻译Chitosan-based scaffolds possess some specialproperties for use in tissue engineering.First,Chitosancan be formed as interconnected-porous structures byfreezing and lyophilizing of chitosan solution or byprocesses such as an “internal b
壳聚糖基支架具备一些特殊
物业的使用在组织工程中.首先,壳聚糖
可以形成相互关联的多孔结构
冻结和冷冻干燥的壳聚糖溶液,或
的进程,如“内部鼓泡过程中（初馏点） ”
如碳酸钙添加到壳聚糖溶液产生
壳聚糖-碳酸钙凝胶在具体的形状,使用合适的
模具（议员和霍尔,2000年） .该interconnectedporous
结构是非常重要的,使众多的细胞
可种子,迁移到内,增加细胞
数目,并应提供足够数量的
养分.多孔结构的壳聚糖是一种很有前途的
特点,为发展和优化一
各种组织棚架和再生艾滋病.规例
孔隙度和孔隙形态的壳聚糖基
棚架是至关重要的控制细胞的殖民统治
利率和组织一工程组织.在…内
此外,血管生成所需的一些脚手架的应用
情景可以受支架的孔隙率和
孔隙形态（ madihally和Matthew ,1999年） .
第二,阳离子的性质,壳聚糖还允许
pH依赖型静电相互作用与阴离子
糖胺聚糖（保密）和蛋白分布式
广泛的整个身体和其他消极
被控物种.这个属性是其中一个重要的
要素组织工程的应用,因为
号码细胞因子/生长因子已知是
约束和调制的gag包括肝素和
硫酸乙酰肝素.棚架纳入壳聚糖
复杂的gag可能服务的手段和挽留人才,并集中
可取的因素分泌的殖民细胞.
此外,西川等人.（ 2000 ）报道,壳聚糖,
在结构上相似的gag与构成的longchain ,
unbranched ,重复糖单位,把
要发挥关键作用,调节细胞形态,分化,
和功能.