英语翻译In a rat fertility and early embryonic development study administered 100,300,or 1000 mg/kg/day for 28 days prior to paring and continued until euthanasia for males,and 14 days prior to pairing to gestation day 7 for females,a decrease in
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英语翻译In a rat fertility and early embryonic development study administered 100,300,or 1000 mg/kg/day for 28 days prior to paring and continued until euthanasia for males,and 14 days prior to pairing to gestation day 7 for females,a decrease in
英语翻译
In a rat fertility and early embryonic development study administered 100,300,or 1000 mg/kg/day for 28 days prior to paring and continued until euthanasia for males,and 14 days prior to pairing to gestation day 7 for females,a decrease in fertility,no or reduced sperm motility,altered estrous cycles,and an increased percentage of abnormal sperm (broken sperm with detached heads) occurred at exposures in males approximately 11 times the human exposure at a dose of 200 mg.The altered sperm effects were reversible at the end of a 9-week drug-free period.
英语翻译In a rat fertility and early embryonic development study administered 100,300,or 1000 mg/kg/day for 28 days prior to paring and continued until euthanasia for males,and 14 days prior to pairing to gestation day 7 for females,a decrease in
一个对老鼠繁殖和早期胚胎发展的研究：
把药物剂量分成三级：100,300和1000毫克/每天每千克的剂量,
在配对前28天开始对公鼠开始注射药物直到公鼠发情位置；而对母鼠,则在配对前14天直到怀孕的第7天注射药物.测试结果是,剂量在200毫克的时候公鼠的生育率下降,精子活力完全或部分缺失,紊乱的发情周期还有异形精子的比率增大等问题上几乎是人类的11倍.药物对精子的影响可以持续到停止注射药物后9周.