英语翻译Natural products (NPs) are small molecules of incredible structural diversity that have long been appreciated for their critical role in drug discovery and development.Production of NPs from biosynthetic gene clusters depends on the coord

英语翻译Natural products (NPs) are small molecules of incredible structural diversity that have long been appreciated for their critical role in drug discovery and development.Production of NPs from biosynthetic gene clusters depends on the coord
英语翻译
Natural products (NPs) are small molecules of incredible structural diversity that have long been appreciated for their critical role in drug discovery and development.Production of NPs from biosynthetic gene clusters depends on the coordinated transcription of relevant genes to messenger RNAs (mRNAs),the translation of these mRNAs to polypeptide chains,and the correct folding of these polypeptides to create functional biosynthetic machineries that cooperate to catalyze the formation of complex structures from simple precursor molecules.Sequencing of numerous actinomycete genomes during the past decade has revealed a stunning number of NP biosynthetic gene clusters,only about 10% of which have been linked to characterized NPs.While bioinformatics-guided efforts have been successful in correlating some of these NP gene clusters to new metabolites,which include those produced by polyketide synthases,nonribosomal peptide synthetases,and terpene synthases,it is clear that our ability to mine these new gene clusters to uncover the chemical potential hidden within them has not kept pace with DNA sequencing technology.We herein choose a few examples from our current research regarding the biosynthesis of pharmaceutical NPs,to show our efforts in methodology development by incorporating NP-forming chemistry into rational mining from strains for which the genome sequence is known or even unknown.

英语翻译Natural products (NPs) are small molecules of incredible structural diversity that have long been appreciated for their critical role in drug discovery and development.Production of NPs from biosynthetic gene clusters depends on the coord
天然产物是指具有难以置信的结构多样性的小分子,长期以来在药物探索和研发上起到了重要作用.天然产物的生物合成取决于协调转录相关基因的信使RNA,翻译这些基因并使肽链正确折叠,而这些多肽与具有加工功能的生物机制合作,促进简单的前体分子形成复杂的结构.在过去十年中,放线菌基因组测序已检测出一些指导天然产物合成的生物基因,但只有约10%的基因产物具有天然产物的特征.虽然生物信息引导已经成功收集了一些自然产物基因的新代谢产物,其中包括那些由聚酮合成酶,非核糖体肽合成酶,和萜烯合成酶,很显然,我们的能力还不足以通过测序技术发现这些新的基因的所隐藏的化学内涵.在此选择几个例子,从我们目前研究的合成药物的天然产品的方法来展示我们在天然产品形成化学中取得的成绩,为合理研究菌株的基因组序列提供可能.

翻译：
天然产品（纳米）的小分子，难以置信的结构的多样性长期以来一直赞赏的重要作用，药物发现和开发。生产的核动力源的生物合成基因簇取决于协调转录相关基因的信使核糖核酸（基因），翻译这些基因肽链正确折叠，而这些多肽创造功能的生物合成机制合作，促进形成复杂的结构从简单的前体分子。放线菌基因组测序许多在过去十年中已显示出惊人的一些国民党的生物合成基因簇，只有约10%的已链接到其核动力源。而bio...

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翻译：
天然产品（纳米）的小分子，难以置信的结构的多样性长期以来一直赞赏的重要作用，药物发现和开发。生产的核动力源的生物合成基因簇取决于协调转录相关基因的信使核糖核酸（基因），翻译这些基因肽链正确折叠，而这些多肽创造功能的生物合成机制合作，促进形成复杂的结构从简单的前体分子。放线菌基因组测序许多在过去十年中已显示出惊人的一些国民党的生物合成基因簇，只有约10%的已链接到其核动力源。而bioinformatics-guided努力已成功在相关的一些这些基因簇的新的代谢产物，其中包括那些由聚酮合成酶，非核糖体肽合成酶，和萜烯合酶，它是明确的，我们的能力，这些新的基因簇发现的化学势隐藏在他们还没有跟上测序技术。我们在此选择几个例子从我们目前的研究有关的生物合成药物粒子，让我们努力在方法论的发展纳入np-forming化学为合理开采从菌株的基因组序列是已知或未知。
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