英语翻译Ca2+信号(Ca2+ signals)调控着细胞内许多重要的功能,参与包括细胞电兴奋、肌肉收缩、囊泡分泌、细胞转录、增殖、分化以及死亡.不同细胞对钙信号的反应不同,在同一细胞中,不同
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英语翻译Ca2+信号(Ca2+ signals)调控着细胞内许多重要的功能,参与包括细胞电兴奋、肌肉收缩、囊泡分泌、细胞转录、增殖、分化以及死亡.不同细胞对钙信号的反应不同,在同一细胞中,不同
英语翻译
Ca2+信号(Ca2+ signals)调控着细胞内许多重要的功能,参与包括细胞电兴奋、肌肉收缩、囊泡分泌、细胞转录、增殖、分化以及死亡.不同细胞对钙信号的反应不同,在同一细胞中,不同形式的钙信号可产生不同的反应.例如在心肌细胞,动作电位导致的Ca2+内流触发细胞收缩;而在病理生理条件下(如心肌肥大),钙信号可通过基因表达激活转录因子,诱导心肌表型重构.对心肌细胞来说,离子钙将细胞的兴奋(即动作电位)与细胞的收缩联系起来,此即为兴奋-收缩耦联(excitation-contraction coupling,ECC).在ECC过程中,心肌细胞的兴奋引起胞膜上的电压依赖性L-型钙通道开放,胞外Ca2+内流,以钙诱导钙释放(Ca2+-induced Ca2+release,CICR)的方式引起心肌细胞肌浆网(sarcoplasmic reticulum,SR)在短时间内通过其膜上的钙释放通道(即ryanodine受体)向胞浆释放大量的钙,造成胞浆内钙离子浓度瞬时升高,此即为钙瞬变(Ca2+ transients).钙瞬变通过肌钙蛋白(troponin)引起细胞收缩[1].通过对钙瞬变的观测,可了解心肌细胞的功能活动特点和状态.因此,我们通过给予不同浓度的药物灌流作用于心室肌细胞,以局部场电刺激的方法诱发全细胞的钙释放(钙瞬变),观察不同浓度的药物对心室肌细胞胞内钙信号的影响,并探讨其发生机制为临床心血管疾病的防治提供一定的理论依据.
英语翻译Ca2+信号(Ca2+ signals)调控着细胞内许多重要的功能,参与包括细胞电兴奋、肌肉收缩、囊泡分泌、细胞转录、增殖、分化以及死亡.不同细胞对钙信号的反应不同,在同一细胞中,不同
Ca2 + Ca2 + signal (it was) regulates the intracellular many important function, including cell electric excited, and participate in muscle contraction, vesicles secretion, cell transcription, proliferation and differentiation, and death. Different cell calcium signal to react differently, in the same cell, the different forms of calcium signal can produce different reaction. For example in the myocardial cells, action potential Ca2 + to internal flow triggering cell contraction, While in pathophysiological conditions (e.g. myocardial hypertrophy), calcium signals can be activated by gene expression transcription factor, induction of myocardial phenotype reconstruction. Of myocardial cells, cells, calcium ions in the excited (namely action potential) and cell contraction connected, this is for excited - contraction coupling (excitation - contraction coupling, ECC). In ECC process, myocardial cell exciting cause cell membrane voltage dependence L - type calcium channel open Ca2 +, exocellular internal flow, with calcium induction Ca2 + - calcium release (Ca2 + release, induced CICR) of the way cause myocardial cell muscle sarcoplasmic reticulum, slurry nets (SR) in a short time through the membrane of calcium release channel (namely ryanodine receptor) to the cytoplasm and release a lot of calcium, causing the cytoplasm calcium ion concentration increases, the instantaneous namely for calcium transients Ca2 + transient (). Calcium transients through muscle calcium protein (troponin) cause cells to contract [1]. Through the observation of calcium transients, can understand myocardial cell function active characteristics and status. Therefore, we by giving different concentrations of drug perfusion effect on ventricular muscle cells, with local field electrical stimulation of the whole cell calcium method induced release (calcium transients), observe different concentrations of drugs on cardiac entricular myocyte intracellular calcium signal influence, and its happening mechanism are discussed for clinical cardioascular disease prevention provide certain theoretical basis.