英文生物学文献谁能给翻一下,急SUMMARYHistone H3 serine 10 phosphorylation is a hallmark ofmitotic chromosomes,but its full function remains tobe elucidated.We report here that two SR proteinsplicing factors,SRp20 and ASF/SF2,associatewit

英文生物学文献谁能给翻一下,急SUMMARYHistone H3 serine 10 phosphorylation is a hallmark ofmitotic chromosomes,but its full function remains tobe elucidated.We report here that two SR proteinsplicing factors,SRp20 and ASF/SF2,associatewit
英文生物学文献谁能给翻一下,急
SUMMARY
Histone H3 serine 10 phosphorylation is a hallmark of
mitotic chromosomes,but its full function remains to
be elucidated.We report here that two SR protein
splicing factors,SRp20 and ASF/SF2,associate
with interphase chromatin,are released from hyperphosphorylated
mitotic chromosomes,but reassociate
with chromatin late in M-phase.Inhibition of
Aurora B kinase diminished histone H3 serine 10
phosphorylation and increased SRp20 and ASF/
SF2 retention on mitotic chromosomes.Unexpectedly,
we also found that HP1 proteins interact with
ASF/SF2 in mitotic cells.Strikingly,siRNA-mediated
knockdown of ASF/SF2 caused retention of HP1
proteins on mitotic chromatin.Finally,ASF/SF2-
depleted cells released from a mitotic block displayed
delayed G0/G1 entry,suggesting a functional
consequence of these interactions.These findings
underscore the evolving role of histone H3 phosphorylation
and demonstrate a direct,functional,and
histone-modification-regulated association of
SRp20 and ASF/SF2 with chromatin.

英文生物学文献谁能给翻一下,急SUMMARYHistone H3 serine 10 phosphorylation is a hallmark ofmitotic chromosomes,but its full function remains tobe elucidated.We report here that two SR proteinsplicing factors,SRp20 and ASF/SF2,associatewit
组蛋白H3丝氨酸磷酸化是有丝分裂染色体一种标志.在这里,我们报告两个SR蛋白剪接因子,SRp20和ASF/SF2,与间期染色质,被释放的有丝分裂磷酸化染色体,但在M与染色质后期阶段重新关联.抑制极光激酶减少组蛋白H3丝氨酸磷酸化和增加SRp20业余/SF2保留在有丝分裂染色体.但是,我们还发现,HP1蛋白相互作用ASF/SF2有丝分裂的细胞.引人注目的是,他干扰RNA介导的ASF/SF2导致HP1保留染色质蛋白对有丝分裂.最后,ASF/SF2-从一个细胞有丝分裂块释放耗尽显示延迟G0/G1期进入,显示功能这些相互作用的结果.这些调查结果强调了组蛋白H3的磷酸化作用的演变并论证了一种直接的组蛋白功能和组蛋白修饰调节修饰SRp20与染色质ASF/SF2.
如果没错的话,这是发表在CELL上的文章吧,我们老师当时给我们看了,简单翻译了一下