英语翻译structure of the Stratum Corneum and Drug Options to Overcome the BarrierThe skin is the largest human organ.It ensures that harmful substances and drugs released from topically applied formulations cannot intrude into the organism offhan

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英语翻译structureoftheStratumCorneumandDrugOptionstoOvercometheBarrierTheskinisthelargesthumanorgan.Iten

英语翻译structure of the Stratum Corneum and Drug Options to Overcome the BarrierThe skin is the largest human organ.It ensures that harmful substances and drugs released from topically applied formulations cannot intrude into the organism offhan
英语翻译
structure of the Stratum Corneum and Drug Options to Overcome the Barrier
The skin is the largest human organ.It ensures that harmful substances and drugs released from topically applied formulations cannot intrude into the organism offhand.The evolutionary development of the human skin as a potential barrier keeping water in and noxious substances out of the human body was a requirement for terrestrial life.Figure 1 illustrates the complex structure of the human skin and the several layers schematically
The outermost layer of the skin,the straum corneum,is of particular interest as it determines this barrier function.The qulification for this is the unique physicochemical composition of the stratum corneum.The 'brick and mortar model'is applied to deseribe the structure of the horny layer.Corneocytes are the 'bricks'embedded in an intercellular lipid matrix of mainly fatty acids,ceramides,cholesterol and cholesterol sulfate.In 1994 a more differentiated variation of this model,the domain mosaic model,was introduced by Forslind.Recently,Norlen postulated two new models for stratum corneum characterization.For skin barrier formation a membrane-folding model was proposed and skin barrier structure and function was simplified by a single gel phase model.

英语翻译structure of the Stratum Corneum and Drug Options to Overcome the BarrierThe skin is the largest human organ.It ensures that harmful substances and drugs released from topically applied formulations cannot intrude into the organism offhan
角质层的药物选择和结构,以克服障碍
皮肤是人体最大的organ.It确保有害物质和局部应用制剂释放药物无法侵入作为一个潜在的保水屏障和有毒物质在人体机体offhand.The出到人体皮肤的进化发展一为陆地life.Figure要求1说明了复杂的结构和人体皮肤的几个层面示意图
对皮肤,straum角质层,最外层是因为它决定了这个屏障功能特别感兴趣.此qulification是地层corneum.The砖雕,并应用于deseribe的角质层结构迫击炮model'is独特的物理化学组成.角质细胞是在一间脂质主要脂肪酸,神经酰胺,胆固醇和胆固醇sulfate.In 1994年这个模型,域镶嵌模型更加分化变异矩阵,是由Forslind.Recently介绍bricks'embedded,Norlen假设两个新对皮肤角质层屏障形成模型characterization.For膜折叠模型,提出和皮肤屏障结构和功能是由一个单一的凝胶相模型简化.

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结构的角质层和药品选项来克服的障碍
皮肤最大的人体器官它不保证有害物质释放和药品剂型局部应用生物不能闯进来演化发展人的肌肤保持水势垒有害物质出人类的身体陆地生活要求图1结构复杂的人类皮肤和好几层schematically
最外层的皮肤,straum角质,是特别感兴趣,因为它决定了这种障碍的功能。因为这是资格的独特的物理化学组成的角质层. “砖和砂浆模型应用于'is篇幅来描述一下结构的角层。Corneocytes是“'embedded在一个细胞间脂质砖主要矩阵的脂肪酸,ceramides、胆固醇和胆固醇硫酸盐. 1994年的变化更分化领域马赛克的模型,在此基础上介绍了模型,Forslind . 最近,两个新模型假定Norlen角质层表征为皮肤屏障的形成了一支membrane-folding提出和皮肤屏障的模型简化结构和功能由单一凝胶阶段模型。

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