英语翻译Recurring cycles of cellular growth and division present a simplequestion:how do cells link these processes and divide only uponreaching an appropriate size?Genetic screens have identified com-ponents in the fission yeast controlling cell

英语翻译Recurring cycles of cellular growth and division present a simplequestion:how do cells link these processes and divide only uponreaching an appropriate size?Genetic screens have identified com-ponents in the fission yeast controlling cell
英语翻译
Recurring cycles of cellular growth and division present a simple
question:how do cells link these processes and divide only upon
reaching an appropriate size?Genetic screens have identified com-
ponents in the fission yeast controlling cell size at division6,7
.The
central factor Cdk1 drives entry into mitosis by phosphorylating a
wide range of targets
8
.In small cells that are in early G2,Cdk1 is kept
inactive by the kinaseWee1,which directly phosphorylates and inhi-
bits Cdk1.As cell size increases during G2,the phosphatase Cdc25
removes this inhibitory phosphorylation to activate Cdk1 and allow
mitotic entry.Thus,the mitotic entry control system coordinates a
balance of Wee1 and Cdc25 activity with changes in cell size to
generate a reproducible cell size at division.Although several factors
regulating Wee1 and Cdc25 have been identified3
,the links between
cell size and the Wee1-Cdc25-Cdk1 module have remained elusive.

英语翻译Recurring cycles of cellular growth and division present a simplequestion:how do cells link these processes and divide only uponreaching an appropriate size?Genetic screens have identified com-ponents in the fission yeast controlling cell
循环周期的细胞生长和简单
问题:如何连接这些过程和分裂细胞只有
达到适当的尺寸吗?遗传屏幕已经鉴定出com -
ponents在裂变酵母细胞尺寸控制在division6,7
.这个
Cdk1中央因素驱使进入一所phosphorylating有丝分裂
广泛的目标
8
.在小细胞Cdk1早期G2,被保留
kinaseWee1激活的,它直接phosphorylates和inhi -
Cdk1位.作为一个单元大小增加,磷酸酶Cdc25精密型矫正
消除这种抑制磷酸化Cdk1启动并允许
有丝分裂的入口.因此,在有丝分裂的输入控制系统配合
Wee1平衡Cdc25活动中,细胞大小
产生一个可再生细胞大小的除法.虽然几个因素
Wee1规范和Cdc25已经identified3
,三者之间的联系
细胞大小和Wee1-Cdc25-Cdk1模块仍然难以捉摸.

循环周期的细胞生长和分裂周期提出一个简单的问题:如何连接这些过程和分裂细胞只有 达到适当的尺寸吗?遗传屏幕已经鉴定出com - ponents在裂变酵母细胞尺寸控制在division6,7 。这个
驱动器的核心因素Cdk1通过磷酸化一进入有丝分裂进入
范围广泛的目标
8
。在小细胞G2的初，Cdk1保持
无效的kinaseWee1，直接磷酸...

全部展开

循环周期的细胞生长和分裂周期提出一个简单的问题:如何连接这些过程和分裂细胞只有 达到适当的尺寸吗?遗传屏幕已经鉴定出com - ponents在裂变酵母细胞尺寸控制在division6,7 。这个
驱动器的核心因素Cdk1通过磷酸化一进入有丝分裂进入
范围广泛的目标
8
。在小细胞G2的初，Cdk1保持
无效的kinaseWee1，直接磷酸化和inhi -
位Cdk1。正如在G2细胞体积的增加，磷酸酶Cdc25
消除这种抑制磷酸化激活Cdk1，让
有丝分裂项。因此，有丝分裂入口控制系统的坐标1
Wee1和Cdc25的活性平衡细胞大小的变化来
在表决产生重复的单元尺寸。虽然有几个因素
规范Wee1和Cdc25已identified3
，之间的联系
单元尺寸和Wee1 - Cdc25 - Cdk1模块仍然难以实现。

收起