帮个忙 翻译一下 不要机器翻译的筛选出和FGFR3结合的活性短肽ACH小鼠BMSC成骨活性增强,矿化能力降低,与FGFR3经ERK1/2促进Cbfa1、OP等表达有关；FGFR3、1均直接及经成骨细胞促进破骨细胞分化及

帮个忙 翻译一下 不要机器翻译的筛选出和FGFR3结合的活性短肽ACH小鼠BMSC成骨活性增强,矿化能力降低,与FGFR3经ERK1/2促进Cbfa1、OP等表达有关；FGFR3、1均直接及经成骨细胞促进破骨细胞分化及
帮个忙 翻译一下 不要机器翻译的
筛选出和FGFR3结合的活性短肽
ACH小鼠BMSC成骨活性增强,矿化能力降低,与FGFR3经ERK1/2促进Cbfa1、OP等表达有关；
FGFR3、1均直接及经成骨细胞促进破骨细胞分化及吸收功能
FGFR3与h1-calponin、ALK3等有crosstalk,共同调节骨骼发育及骨稳定
用条件性基因敲除技术发现FGFR1抑制成骨细胞增生、分化,成骨细胞敲除FGFR1的小鼠骨量增加,有自发骨折,ALK3降低在其中起重要作用
在破骨细胞敲除FGFR1的小鼠骨量增加,骨折愈合延迟
用基因敲入技术建立模拟人Apert综合症的小鼠模型,发现FGFR2突变经ERK1/2同时影响软骨及成骨细胞发育导致囟门早闭
建立FGFR3条件性敲除小鼠及其它10余种转基因小鼠模型.
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帮个忙 翻译一下 不要机器翻译的筛选出和FGFR3结合的活性短肽ACH小鼠BMSC成骨活性增强,矿化能力降低,与FGFR3经ERK1/2促进Cbfa1、OP等表达有关；FGFR3、1均直接及经成骨细胞促进破骨细胞分化及
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筛选出和FGFR3结合的活性短肽
The selection of active peptide binding with FGFR3
ACH小鼠BMSC成骨活性增强,矿化能力降低,与FGFR3经ERK1/2促进Cbfa1、OP等表达有关；
The BMSC osteogenic activities of ACH mice enhanced, mineralization capability reduced, these are related to the Cbfa1, OP expression promoted by FGFR3 with ERK1/2.
FGFR3、1均直接及经成骨细胞促进破骨细胞分化及吸收功能
Directly and through the osteoblasts, FGFR 3 and 1 both promoted the differentiation and absorption functions of the osteoclasts.
FGFR3与h1-calponin、ALK3等有crosstalk,共同调节骨骼发育及骨稳定
FGFR3 and h1-calponin, ALK3 all possessed crosswalk and jointly regulated skeletal growth and stability.
用条件性基因敲除技术发现FGFR1抑制成骨细胞增生、分化,成骨细胞敲除FGFR1的小鼠骨量增加,有自发骨折,ALK3降低在其中起重要作用
By applying conditional gene knockout technique, it was found that FGFR1 inhibited the hyperplasia and differentiation of osteoblasts; and bone mass increase and spontaneous fracture were observed on the osteoblast knockout FGFR1 mice, the reduction of ALK3 was an important factor.
在破骨细胞敲除FGFR1的小鼠骨量增加,骨折愈合延迟
Increase in bone mass and delay on fracture healing were observed on the osteoclast knockout FGFR1 mice.
用基因敲入技术建立模拟人Apert综合症的小鼠模型,发现FGFR2突变经ERK1/2同时影响软骨及成骨细胞发育导致囟门早闭
On the mice model simulating Apert Syndrome on human obtained by using the gene knock-in technique, mutation was found in FGFR2 with ERK1/2, at the same time affecting the development of cartilage and osteoblasts resulting in early fontanel closure.
建立FGFR3条件性敲除小鼠及其它10余种转基因小鼠模型.
Establish FGFR3 conditional knockout mice and more than ten other transgenic mice models.

The 筛 selects with the live and short 肽 that the FGFR3 join together
Small rat BMSC of ACH ossification the activity strengthen, 矿化 the ability lower, and was promoted by ERK1/2 with FGFR3 Cbfa1,...

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The 筛 selects with the live and short 肽 that the FGFR3 join together
Small rat BMSC of ACH ossification the activity strengthen, 矿化 the ability lower, and was promoted by ERK1/2 with FGFR3 Cbfa1, OP...etc. expresses relevant;
FGFR3,1 all direct and was promoted by ossification cell to break the 骨 cell to divide and absorb the function
FGFR3 and h1- calponin, ALK3...etc. contain crosstalk, and together regulate the skeleton growth and 骨 stability
Use small rat 骨 that term the gene knock to divided by the technique to discovers FGFR1 repressing the ossification cell to increase to living, divide, and the ossification cell knock to divided by the FGFR1 to measure to increase, have the self-moving bone fracture, ALK3 to lower amid rise the important function
At break the small rat 骨 that 骨 cell knock to divided by the FGFR1 to measure to increase, and the bone fracture more match the delay
Gene that knock into the technique to establish the small rat model to synthesize the 症 with emulation person's Apert, discovers FGFR2 mutation through the ERK1/2 at the same time affecting the cartilage and ossification cell the growth to cause the 囟 door to shut early
Establish the FGFR3 the term to knock to divided by the small rat and other 10 remainings grow to turn the small rat model of gene.

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