英语翻译Naltrexone,an orally effective,long-lasting opiate receptorantagonist,was approved by the FDA for treating alcohol and opiateaddiction in 1984,but its general patent expired the followingyear.It is a non-selective antagonist,with robust e

英语翻译Naltrexone,an orally effective,long-lasting opiate receptorantagonist,was approved by the FDA for treating alcohol and opiateaddiction in 1984,but its general patent expired the followingyear.It is a non-selective antagonist,with robust e
英语翻译
Naltrexone,an orally effective,long-lasting opiate receptor
antagonist,was approved by the FDA for treating alcohol and opiate
addiction in 1984,but its general patent expired the following
year.It is a non-selective antagonist,with robust effects on pleasure
promoting mu opioid receptors (MOR) and delta opioid receptors
(DOR) [1],with less antagonism of aversion-mediating kappa
opioid receptors (KOR) [2] but substantial effect on the more recently
discovered orphanin FQ or nociceptin [N/OFQ] opioid family
[3].The benefits of high dose naltrexone in narcotic addiction are
explained by blockade of all pleasure producing effects of opioids,
and similar mechanisms may explain the ability of naltrexone to
reduce binging on alcohol.

英语翻译Naltrexone,an orally effective,long-lasting opiate receptorantagonist,was approved by the FDA for treating alcohol and opiateaddiction in 1984,but its general patent expired the followingyear.It is a non-selective antagonist,with robust e
纳曲酮（化学名环丙甲羟二羟吗啡酮——译者注）系口服长效阿片（类）受体拮抗剂,1984年经FDA（美国食品药品监督局——译者注）获准用于治疗酒精成瘾、阿片成瘾；而其通用专利已超规定年限.该药为非选择性拮抗剂,对Μ型受体（MOR）、Δ型受体（DOR）所致满足（感）有强效【1】,而对厌-和类K型阿片受体（KOR）拮抗效力较弱【2】,但对新近发现的孤啡肽或致痛素【N/OFQ】类阿片样物质确有实效【3】.高剂量纳曲酮对镇静剂成瘾的药效（获益）在于,可阻断阿片类效应产生的种种满足（感）,其抑制酒精（所致）狂瘾的机制与此类似.
供参

纳曲酮，一个口头有效，长久鸦片制剂受体拮抗剂，被批准被食品及药物管理局为治疗酒精，鸦片制剂瘾1984年，但它的普通专利到期第二年。它一个非选择性对手，同健壮影响乐趣促进亩阿片受体(粗腐殖质)，三角洲阿片受体同少aversion-mediating的对抗卡帕阿片受体然而大量对有影响最近发现孤啡肽或故又称痛敏肽,然而大量对有影响最近发现孤啡肽或故又称痛敏肽孤啡肽阿片样物质家庭高剂量的利益纳曲酮在麻醉的...

全部展开

纳曲酮，一个口头有效，长久鸦片制剂受体拮抗剂，被批准被食品及药物管理局为治疗酒精，鸦片制剂瘾1984年，但它的普通专利到期第二年。它一个非选择性对手，同健壮影响乐趣促进亩阿片受体(粗腐殖质)，三角洲阿片受体同少aversion-mediating的对抗卡帕阿片受体然而大量对有影响最近发现孤啡肽或故又称痛敏肽,然而大量对有影响最近发现孤啡肽或故又称痛敏肽孤啡肽阿片样物质家庭高剂量的利益纳曲酮在麻醉的的瘾被说明附近的的封锁线的所有乐趣生产阿片类药物的影响，类似的机制可能说明能力的纳曲酮减少粘合在酒精。

收起